In a world distorted by a cataclysm, an amnesiac, mute young man must explore the halls of the Neuro-Tower to unearth what caused the disaster and how his own past ties into the events. Originally released in 1998, it wasn't released outside of Japan until 2008.
The second in the Devil Summoner series, Soul Hackers follows a group called the Spookies as they attempt to stop an overflow of demons in a city where the internet is all-pervasive. Released in 1997, it anticipated a future dominated by the internet and depicted a fictional virtual-reality cyberspace city called Paradigm X.
Castlevania: Symphony of the Night is a 2D action-adventure platformer. Its open-ended gameplay mixed with RPG mechanics set the template for later Castlevania games, and its critical acclaim led to the coining of the term Metroidvania.
Enemy Zero is a game developed by Kenji Eno in which all of the enemies are invisible, and their types and positions can only be determined from the sounds they make.
Resident Evil is a survival horror classic in which a group of special forces agents, known as S.T.A.R.S, struggle against hordes of zombies and various other mutants in a mysterious mansion as they try to uncover the truth behind the terrifying infection. The game is credited for coining the phrase "survival horror" and popularizing the genre.
Absolutely horrifying game and a nod to Lovecraftian horror. Wish more similar games came out.